Pharmacotherapy gi disorders indigestion peptic ulcer. Effect on persistent or rebleeding of peptic ulcer in patients with peptic ulcer and h. Peptic ulcer bleeding is a common and potentially fatal condition. The pathophysiology of peptic ulcer disease pud is often described as an imbalance between aggressive factors such as acid and pepsin and alterations in the mucosal protective mechanisms. Current trends in the pharmacotherapy for peptic ulcer. New york chicago san francisco lisbon london madrid mexico city milan new delhi san juan seoul singapore sydney toronto pharmacotherapy casebook a patientfocused. Start studying pharmacology chapter 62 pharmacotherapy of peptic ulcer disease. Basic concepts of pharmacotherapy principles and practices. Seventy percent to 90% of peptic duodenal and gastric ulcers will heal after 4 to 8 weeks of therapy. Peptic ulcer disease represents a serious medical problem. Patients with peptic ulcer disease pud should reduce psychological stress, cigarette smoking, and nonsteroidal antiinflammatory drug nsaid use and avoid foods and beverages that exacerbate ulcer symptoms.
These typically include proton pump inhibitors like. A cost analysis of alternative treatments for duodenal ulcer. Current trends in the pharmacotherapy for peptic ulcer disease. A peptic ulcer disease or pud is an ulcer defined as mucosal erosions equal to or greater than 0. Peptic ulcer disease is common condition throughout the world.
Evidencebased clinical practice guidelines for peptic. Doctors only prescribe one protectantsucralfate carafatefor peptic ulcer disease. Gastric ulcers, in the stomach, and duodenal ulcers, in the upper portion of the small intestine, occur most often. Drugs that control gastric acid secretion and treat peptic ulcers. Eradication is recommended for all helicobacter pyloripositive patients, especially those patients with an active ulcer, a documented history of a prior ulcer, or a history of ulcer. Although no studies are available on nrts effects on ulcer disease, nicotine may delay healing of active ulcers. Pharmacology chapter 62 pharmacotherapy of peptic ulcer. Epidemiological data for this disease and its complications have. Bushra hasan khan junior resident1, department of pharmacology, jnmc,amu,aligarh.
South texas veterans health care system, san antonio, tx. Pharmacotherapy gi disorders free download as powerpoint presentation. Pharmacotherapy of peptic ulcer linkedin slideshare. Epidemiology etiopathophysiology history of drug development pharmacological agents used in treatment moa, pharmacokinetics, clinical uses, adverse drug reactions eradication of. The discovery of helicobacter pylori as a cause of peptic ulcer has changed our approach greatly towards this disease.
Pharmacokinetics and pharmacodynamics of important groups of. In the antrum 60% at the junction of the antrum and body on the lesser curvature 25% major causes of peptic ulcer disease. Seventy percent to 90% of peptic duodenal and gastric ulcers will heal after 4. Ulcers affect 1114% of men and 811% of women at some time in their lives. The most common remedy is a combination of antibiotic drugs to kill the h.
Pdf the etiology of peptic ulcer is multifactorial. It is important to confirm that an ulcer is present, by either endoscopy or an upper gi radiographic series, before treatment is initiated. It is best managed using a multidisciplinary approach by a team with medical. The healing rare increases with time for active medication and placebo, and is lower among smokers than nonsmokers for all drugs but misoprostol.
Most patients in the hospital setting will have been referred. Pdf pharmacotherapy of peptic ulcer disease and latest research. Jsge revised the evidencebased clinical practice guidelines for peptic ulcer disease in 2014 and has created an english version. Content outline for the pharmacotherapy certification examination the following domains, tasks and knowledge statements were delineated by the bps specialty council on pharmacotherapy and validated through a role delineation study. Lack of response to conventional treatment for peptic ulcer disease should suggest conditions other than benign peptic ulcers, and should warrant endoscopy or. The goals of pharmacotherapy are to eradicate h pylori infection, to reduce morbidity, and to prevent complications in patients with peptic ulcers. Drinking alcohol and smoking slow the healing of a peptic ulcer and can. An estimated 15,000 deaths per year occur as a consequence of complication of peptic ulcers. Peptic ulcer disease pud is one of the most common diseases affecting the gastroinestinal gi tract. The stomach is an outpocket of the gastrointestinal tract in which ingested food undergoes mechanical and chemical changes that promote absorption in the small and large intestine. Pdf on aug 19, 2019, balaji ommurugan and others published pharmacotherapy of peptic ulcer disease and latest research find, read and cite all the research you need on researchgate.
Pharmacotherapy of duodenal and gastric ulcerations. Tell your doctor if the medicines make you feel sick or dizzy or cause diarrhea or headaches. Pharmacotherapy of peptic ulcer disease and gastroesophageal reflux disease gerd peptic ulcer disease and gerd are best treated with a combination of pharmacotherapy and lifestyle changes to relieve symptoms, promote healing and prevent complications and recurrence key factors. The recommended treatment for severe peptic ulcer bleeding after appropriate endoscopic treatment is the iv administration of a ppi loading dose followed by a. Interestingly, those at the highest risk of contracting peptic ulcer disease are those generations born around the middle of the 20th century. Based on the high incidence and the enormous amount of money that is spent on peptic ulcer disease, it is very important for pharmacists and pharmacy students to be educated about this disease and the medication regimens. Content acid peptic disease gastric anatomy and gastric physiology what is peptic ulcer. Pdf pharmacotherapy of peptic ulcer disease and latest. A variety of options are available for the medical treatment of peptic ulcer disease, including antacids, histamine 2 receptor antagonists, omeprazole, prostaglandin analogues, and sucralfate and bismuth formulations. A variety of options are available for the medical treatment of peptic ulcer disease, including antacids, histamine2 receptor antagonists, omeprazole, prostaglandin analogues, and sucralfate and bismuth formulations. The final module includes three new interactive features. Contents physiology of gastric acid secretion an introduction to peptic ulcer disease drugs used in pud 2 3. Which of the following is not a common cause of peptic ulcer disease pud. The studies of prescribing patterns of gastric acid suppressant treatment in peptic ulcer disease suggest a more frequent use of histamine h2.
Pharmacotherapy education and research center, university of texas health science center at san antonio. Descriptive epidemiology, risk factors, management and prevention. Approximately 500,000 new cases are reported each year, with 5 million people affected in the united states alone. In united states alone around 4 million individuals are affected. The mortality from peptic ulcer disease has similarly decreased over the same interval, which has been attributed to increased helicobacter pylori eradication rates and the widespread adoption of acidsuppression medications. Peptic ulcer disease usually occurs in the stomach and proximal duodenum. Diagnosis and treatment of peptic ulcer disease and h. Scribd is the worlds largest social reading and publishing site. The role of helicobacter pylori in peptic ulcer disease. Division of pharmacotherapy, the university of texas at austin college of pharmacy. Dipiro jt, talbert rl, yee gc, matzke gr, wells bg, posey ml, eds. Peptic ulcer disease and its complications cost the u. Alternative management strategies for patients with suspected peptic ulcer disease.
Peptic ulcers have unquestionably been a disease of the twentieth century. The third module covers gastroesophageal reflux disease and peptic ulcer disease. Drug treatment of peptic ulcer disease open access ebooks. Adefinitive diagnosis of peptic ulcer disease pud can only be made by performing an endoscopy. Peptic ulcer disease pharmacotherapy linkedin slideshare. Pharm, class of 2018 sop, china pharmaceutical university nanjing, jiangsu, chn 211198. Several classes of drugs that are able to efficiently treat some of these diseases have been developed. Pharmacotherapy clinical approaches peptic ulcer disease pud tom hsiung, b. Peptic ulcer is a break like a sore in the lining of the stomach or the upper part of the small intestine 1, with a diameter of at least 0. Nih consensus development panel on helicobacter pylori in peptic ulcer disease.
Peptic ulcer disease peptic ulcer is defined as disruption of the mucosal integrity of the stomach andor duodenum leading to a local defect or excavation due to active inflammation. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Adjuvant pharmacotherapy for peptic ulcer bleeding. The authors of this study used the ambiguous term concomitant disease that made inclusion inappropriate as a criterion for exclusion. Constipation, diarrhea, and irritable bowel syndrome 22. Peptic ulcer can occur at any age, although they are rare in children. Weigh risks and benefits of nrt in patients with active ulcer. Peptic ulcer disease pharmacological treatment pharmaceutical.
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